Thrombophilia and Infertility

Thrombophilia can have an impact on women’s childbearing capacity: a number of scientific studies have associated thrombophilia and recurrent pregnancy losses.

Recurrent pregnancy losses involve the spontaneous miscarriage of the foetus by the woman before the 20th week of gestation in two or more consecutive pregnancies.

For women with this problem, it may be appropriate to investigate a possible cause of genetic thrombophilia, to take the right measures if the physician deems it opportune.

Thrombophilia and women’s health

Further, thrombophilia may be especially relevant for women in specific situations that increase their risk of thrombosis. For example:

  • Taking hormonal contraceptives: certain types of oral contraceptives have been related with a higher incidence of thrombosis.
  • Pregnancy: at the physiological level, the body tends to favour coagulation at this time to counter any possible complications that may have occurred during birth.

A female patient with thrombophilia in these circumstances could have a greater risk of developing thrombosis. Therefore the doctor may recommend prevention measures if deemed appropriate.


Thrombo inCode® Reproductive Health is a personalized medicine genetic test that studies the involvement of thrombophilia in specific situations that may affect women.

  • It analyses 12 genetic variants associated with thrombophilia.
  • It analyses the possible involvement of genetic thrombophilia in the situation of pregnancy losses.
  • It gives recommendations for treatment and prevention measures if any are necessary.
  • It calculates the risk of thrombosis in patients during pregnancy, birth, puerperium* and when taking contraceptives.

(* a name for the period of 6-8 weeks following birth)

The test can be performed using a blood or saliva sample.

Who is it for?

Women who have suffered recurrent pregnancy losses for indefinite causes.

Benefits for physician and patient

  • Determine whether genetic thrombophilia has been a cause of recurrent pregnancy losses to take any necessary measures in future pregnancies
  • Establish prevention measures in the event of high risk of thrombosis during pregnancy, and choose the most suitable type of contraceptives for the patient.
  • Inform the patient of her thrombophilic profile to take it into account in situations that increase the risk of thrombosis.


Recurrent Miscarriage Predictive Capacity Using Thrombo inCode.
J.A. Páramo, J. Bellver, P. Llamas, S. Cabanillas, R. Lecumberri, P. Alamá, A. GarcíaRaso, A. Alfonso, V.H. Gómez, C. Miranda, C. Díaz, K. Guillén, S. Pich, I. Ortega, E. Salas
Poster presentado en el Congreso de la Sociedad Internacional de Hematología, Berlín 2017.

Prediction of thrombophilia-related recurrent pregnancy loss by a new genetic risk score
Bellver J, Alamá MP, Gómez VH, Cabanillas S, Guillén K, Pich S, Ortega I, Salas
Presentación oral en el Congreso Nacional de la Sociedad Española de Fertilidad, Málaga 2016

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To know how the test is done and how to request a test or contact us click here.